5vt2

X-ray diffraction
2.3Å resolution

Crystal structure of growth differentiation factor

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth/differentiation factor 15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 112 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99988 (Residues: 197-308; Coverage: 40%)
Gene names: GDF15, MIC1, PDF, PLAB, PTGFB
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P3121
Unit cell:
a: 64.72Å b: 64.72Å c: 172.53Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.242
Expression system: Escherichia coli BL21