PDBe 5vqp

X-ray diffraction
2.9Å resolution

Crystal structure of human pro-TGF-beta1

Source organism: Homo sapiens
Primary publication:
Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1.
OpenAccess logo J. Biol. Chem. (2017)
PMID: 29109152

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transforming growth factor beta-1 proprotein Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 41.49 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P01137 (Residues: 30-390; Coverage: 100%)
Gene names: TGFB, TGFB1
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P622
Unit cell:
a: 104.39Å b: 104.39Å c: 141.9Å
α: 90° β: 90° γ: 120°
R R work R free
0.254 0.252 0.293
Expression system: Cricetulus griseus