Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Coagulation factor Xa complex and RNA (preferred)
PDBe Complex ID:
PDB-CPX-133215 (preferred)
Entry contents:
2 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
Activated factor Xa heavy chain
Molecule details ›
Chain: H
Length: 233 amino acids
Theoretical weight: 26.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 233 amino acids
Theoretical weight: 26.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P00742 (Residues: 235-467; Coverage: 51%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain
Molecule details ›
Chain: L
Length: 51 amino acids
Theoretical weight: 5.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
Length: 51 amino acids
Theoretical weight: 5.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P00742 (Residues: 128-178; Coverage: 11%)
Sequence domains: Coagulation Factor Xa inhibitory site
Structure domains: Laminin
