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Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Electron Microscopy
7.9Å resolution
PDB entry 5vhp coloured by chain, front view.
PDB entry 5vhp coloured by chain, side view.
PDB entry 5vhp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero octamer (preferred)
Entry contents: 8 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Proteasome complex
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Multimeric state: hetero octamer
Accessible surface area: 124308.53 Å2
Buried surface area: 11738.34 Å2
Dissociation area: 4,118.31 Å2
Dissociation energy (ΔGdiss): -47.84 kcal/mol
Dissociation entropy (TΔSdiss): 84.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131140

Macromolecules

26S proteasome non-ATPase regulatory subunit 10
Chain: G
Length: 224 amino acids
Theoretical weight: 24.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75832 (Residues: 3-226; Coverage: 99%)
Gene name: PSMD10
Pfam: Ankyrin repeats (3 copies)
InterPro:
26S proteasome non-ATPase regulatory subunit 10 in PDB entry 5vhp, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 10 in PDB entry 5vhp, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 10 in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 7
Chain: A
Length: 266 amino acids
Theoretical weight: 29.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35998 (Residues: 159-424; Coverage: 61%)
Gene names: MSS1, PSMC2
Pfam:
InterPro:
26S proteasome regulatory subunit 7 in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 7 in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 7 in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 4
Chain: B
Length: 266 amino acids
Theoretical weight: 29.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62191 (Residues: 167-432; Coverage: 61%)
Gene name: PSMC1
Pfam:
InterPro:
26S proteasome regulatory subunit 4 in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 4 in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 4 in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 6B
Chain: D
Length: 262 amino acids
Theoretical weight: 29.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P43686 (Residues: 145-406; Coverage: 63%)
Gene names: MIP224, PSMC4, TBP7
Pfam:
InterPro:
26S proteasome regulatory subunit 6B in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 6B in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 6B in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 10B
Chain: E
Length: 262 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62333 (Residues: 128-389; Coverage: 67%)
Gene names: PSMC6, SUG2
Pfam:
InterPro:
26S proteasome regulatory subunit 10B in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 10B in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 10B in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 6A
Chain: F
Length: 267 amino acids
Theoretical weight: 29.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P17980 (Residues: 166-432; Coverage: 61%)
Gene names: PSMC3, TBP1
Pfam:
InterPro:
26S proteasome regulatory subunit 6A in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 6A in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 6A in PDB entry 5vhp, assembly 1, top view.
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26S proteasome regulatory subunit 8
Chain: C
Length: 266 amino acids
Theoretical weight: 29.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62195 (Residues: 130-395; Coverage: 66%)
Gene names: PSMC5, SUG1
Pfam:
InterPro:
26S proteasome regulatory subunit 8 in PDB entry 5vhp, assembly 1, front view.
26S proteasome regulatory subunit 8 in PDB entry 5vhp, assembly 1, side view.
26S proteasome regulatory subunit 8 in PDB entry 5vhp, assembly 1, top view.
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26S proteasome non-ATPase regulatory subunit 2
Chain: f
Length: 784 amino acids
Theoretical weight: 86.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13200 (Residues: 70-853; Coverage: 86%)
Gene names: PSMD2, TRAP2
Pfam:
InterPro:
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5vhp, assembly 1, front view.
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5vhp, assembly 1, side view.
26S proteasome non-ATPase regulatory subunit 2 in PDB entry 5vhp, assembly 1, top view.
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