5ve6

X-ray diffraction
2.95Å resolution

Crystal structure of Sugen kinase 223

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive tyrosine-protein kinase PRAG1 Chain: A
Molecule details ›
Chain: A
Length: 492 amino acids
Theoretical weight: 54.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86YV5 (Residues: 932-1406; Coverage: 34%)
Gene names: PRAG1, SGK223
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 144.683Å b: 144.683Å c: 47.445Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.218 0.262
Expression system: Escherichia coli