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CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue

X-ray diffraction
2.08Å resolution
PDB entry 5vd7 coloured by chain, front view.
PDB entry 5vd7 coloured by chain, side view.
PDB entry 5vd7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Wee1-like protein kinase
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Multimeric state: monomeric
Accessible surface area: 13132.74 Å2
Buried surface area: 356.71 Å2
Dissociation area: 115.37 Å2
Dissociation energy (ΔGdiss): -2.57 kcal/mol
Dissociation entropy (TΔSdiss): 0.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151698

Macromolecules

Wee1-like protein kinase
Chain: A
Length: 289 amino acids
Theoretical weight: 32.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30291 (Residues: 291-575; Coverage: 44%)
Gene name: WEE1
Pfam: Protein kinase domain
InterPro:
CATH:
Wee1-like protein kinase in PDB entry 5vd7, assembly 1, front view.
Wee1-like protein kinase in PDB entry 5vd7, assembly 1, side view.
Wee1-like protein kinase in PDB entry 5vd7, assembly 1, top view.
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