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CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (de-phosphorylated) IN COMPLEX WITH SARACATINIB

X-ray diffraction
1.8Å resolution
PDB 5vd3 coloured by chain and viewed from the front.
PDB 5vd3 coloured by chain and viewed from the side.
PDB 5vd3 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14600 Å2
Buried surface area: 1600 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 1 kcal/mol
Symmetry number: 1

Macromolecules

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Chain: A
Length: 311 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99640 (Residues: 75-362; Coverage: 58%)
Gene names: MYT1, PKMYT1
Pfam: Protein kinase domain
InterPro:
PDB 5vd3 contains 1 copy of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase in assembly 1. This protein is highlighted and viewed from the front.
PDB 5vd3 contains 1 copy of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase in assembly 1. This protein is highlighted and viewed from the side.
PDB 5vd3 contains 1 copy of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase in assembly 1. This protein is highlighted and viewed from the top.
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