Structure analysis

CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14500 Å2
Buried surface area: 1200 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Interface energy (ΔGint): 0 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 311 amino acids
Theoretical weight: 34.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99640 (Residues: 75-362; Coverage: 58%)
Gene names: MYT1, PKMYT1
Pfam: Protein kinase domain
InterPro:
CATH:

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