Structure analysis

IL-17A in complex with peptide

X-ray diffraction
1.7Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 12845.34 Å2
Buried surface area: 9186.43 Å2
Dissociation area: 1,772.38 Å2
Dissociation energy (ΔGdiss): 8.66 kcal/mol
Dissociation entropy (TΔSdiss): 16.65 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-166203
Assembly 2 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 11149.58 Å2
Buried surface area: 9300.57 Å2
Dissociation area: 1,803.82 Å2
Dissociation energy (ΔGdiss): 10.55 kcal/mol
Dissociation entropy (TΔSdiss): 16.64 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-166203

Macromolecules

Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.75 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q16552 (Residues: 38-155; Coverage: 89%)
Gene names: CTLA8, IL17, IL17A
Pfam: Interleukin-17
InterPro:
CATH: Cystine-knot cytokines

Search similar proteins

Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.85 KDa
Source organism: synthetic construct
Expression system: Not provided

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