PDBe 5vb6

X-ray diffraction
2.04Å resolution

X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-gamma; Nuclear receptor coactivator 2 Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 32.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15596 (Residues: 685-697; Coverage: 1%)
  • Canonical: P51449 (Residues: 260-507; Coverage: 48%)
  • nullnull
Gene names: BHLHE75, NCOA2, NR1F3, RORC, RORG, RZRG, SRC2, TIF2
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41212
Unit cell:
a: 62.305Å b: 62.305Å c: 154.178Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.208
Expression system: Escherichia coli BL21(DE3)