X-ray diffraction
2.61Å resolution

Crystal Structure of Beta-Klotho in Complex with FGF21CT


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-klotho Chain: A
Molecule details ›
Chain: A
Length: 954 amino acids
Theoretical weight: 109.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q86Z14 (Residues: 30-983; Coverage: 91%)
Gene name: KLB
Sequence domains: Glycosyl hydrolase family 1
Nb914 Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 14.84 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Fibroblast growth factor 21 Chain: C
Molecule details ›
Chain: C
Length: 24 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9NSA1 (Residues: 186-209; Coverage: 13%)
Gene names: FGF21, UNQ3115/PRO10196

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 48.647Å b: 145.487Å c: 213.827Å
α: 90° β: 90° γ: 90°
R R work R free
0.193 0.191 0.229
Expression systems:
  • Homo sapiens
  • Escherichia coli
  • Not provided