5va2

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the human ether-a-go-go related K+ channel

Released:
Source organism: Homo sapiens
Primary publication:
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K(+) Channel hERG.
Cell 169 422-430.e10 (2017)
PMID: 28431243
Related structures: EMD-8651

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer (preferred)
monomeric
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 2 Chain: A
Molecule details ›
Chain: A
Length: 825 amino acids
Theoretical weight: 92.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12809 (Residues: 1-1159; Coverage: 70%)
  • Best match: Q12809-6 (Residues: 24-460)
Gene names: ERG, ERG1, HERG, KCNH2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-8651
Expression system: Homo sapiens