X-ray diffraction
3.1Å resolution

Function and Biology Details

Reaction catalysed:
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cyclic GMP-AMP synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 362 amino acids
Theoretical weight: 42.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8N884 (Residues: 161-522; Coverage: 69%)
Gene names: C6orf150, CGAS, MB21D1
Sequence domains: Mab-21 protein

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 216.729Å b: 48.06Å c: 89.488Å
α: 90° β: 110.65° γ: 90°
R R work R free
0.225 0.224 0.252
Expression system: Escherichia coli