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Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAM

Source organism: Homo sapiens
Biochemical function: histone H3K36 methyltransferase activity
Biological process: not assigned
Cellular component: nucleus

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EC 2.1.1.359: [Histone H3]-lysine(36) N-trimethyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(36)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(36) N(6)-trimethyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00856
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
The deposited structure of PDB entry 5v21 contains 1 copy of Pfam domain PF00856 (SET domain) in Histone-lysine N-methyltransferase SETD2. Showing 1 copy in chain A.

PF17907
Domain description: AWS domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
The deposited structure of PDB entry 5v21 contains 1 copy of Pfam domain PF17907 (AWS domain) in Histone-lysine N-methyltransferase SETD2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001214
Domain description: SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
IPR006560
Domain description: AWS domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
IPR046341
Domain description: SET domain superfamily
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
IPR003616
Domain description: Post-SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
IPR044437
Domain description: SETD2/Set2, SET domain
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2
IPR042294
Domain description: Histone-lysine N-methyltransferase SETD2, animal
Occurring in:
  1. Histone-lysine N-methyltransferase SETD2

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