› 5ur9

X-ray diffraction
2.2Å resolution

Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP5

Released:
DOI: 10.2210/pdb5ur9/pdb
PDB entry 5ur9 coloured by chain, front view.
PDB entry 5ur9 coloured by chain, side view.
PDB entry 5ur9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.
Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H
Biochemistry 56 3454-3462 (2017)
PMID: 28632393

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein 5 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 138 amino acids
Theoretical weight: 15.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01469 (Residues: 1-135; Coverage: 100%)
Gene name: FABP5
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

4 bound ligands:
Ligand 8KS 8 x 8KS
Ligand SO4 15 x SO4
Ligand MYR 4 x MYR
Ligand 1PE 2 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P1
Unit cell:
a: 68.99Å b: 78.11Å c: 78.83Å
α: 61.66° β: 69.61° γ: 78.01°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Maccarrone et al. (2023)
1 more

4 mentions without citation

SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins.
Yan et al. (2018)
3 more