EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
EC 3.6.5.2: Small monomeric GTPase
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)
GO terms
Biochemical function:
- ubiquitin protein ligase activity
- identical protein binding
- apolipoprotein A-I receptor binding
- GBD domain binding
- thioesterase binding
- mitogen-activated protein kinase kinase kinase binding
- GTP-dependent protein binding
- protein kinase binding
- hydrolase activity
- GTP binding
- protein binding
- G protein activity
- GTPase activity
- ATP binding
- protein kinase activity
- protein serine/threonine kinase activity
Biological process:
- positive regulation of substrate adhesion-dependent cell spreading
- modification of synaptic structure
- regulation of postsynapse organization
- regulation of modification of postsynaptic structure
- positive regulation of intracellular protein transport
- actin filament branching
- endothelin receptor signaling pathway involved in heart process
- organelle transport along microtubule
- cellular response to type II interferon
- dendritic spine morphogenesis
- submandibular salivary gland formation
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- Wnt signaling pathway, planar cell polarity pathway
- heart contraction
- regulation of attachment of spindle microtubules to kinetochore
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- positive regulation of synapse structural plasticity
- establishment of Golgi localization
- establishment of localization in cell
- nucleus localization
- positive regulation of stress fiber assembly
- regulation of stress fiber assembly
- positive regulation of filopodium assembly
- regulation of filopodium assembly
- positive regulation of cellular component organization
- neuron fate determination
- positive regulation of pinocytosis
- filopodium assembly
- positive regulation of JNK cascade
- positive regulation of DNA replication
- establishment of epithelial cell apical/basal polarity
- modulation by host of viral process
- positive regulation of neuron apoptotic process
- positive regulation of MAPK cascade
- neuropilin signaling pathway
- dendritic cell migration
- establishment or maintenance of apical/basal cell polarity
- embryonic heart tube development
- adherens junction organization
- cell junction assembly
- regulation of actin cytoskeleton organization
- Cdc42 protein signal transduction
- positive regulation of cytokinesis
- negative regulation of protein-containing complex assembly
- positive regulation of pseudopodium assembly
- positive regulation of cell migration
- positive regulation of cell growth
- macrophage differentiation
- cell differentiation
- actin cytoskeleton organization
- substantia nigra development
- positive regulation of lamellipodium assembly
- regulation of lamellipodium assembly
- anatomical structure morphogenesis
- protein localization
- nervous system development
- small GTPase-mediated signal transduction
- integrin-mediated signaling pathway
- establishment or maintenance of cell polarity
- nuclear migration
- regulation of mitotic nuclear division
- Golgi organization
- actin filament organization
- phagocytosis, engulfment
- endocytosis
- cardiac neural crest cell migration involved in outflow tract morphogenesis
- cardiac conduction system development
- heart process
- sprouting angiogenesis
- protein phosphorylation
Cellular component:
- glutamatergic synapse
- Schaffer collateral - CA1 synapse
- mitotic spindle
- cell periphery
- extracellular exosome
- spindle midzone
- phagocytic vesicle
- apical part of cell
- organelle
- dendritic spine
- neuronal cell body
- neuron projection
- cell projection
- cytoplasmic ribonucleoprotein granule
- protein-containing complex
- leading edge membrane
- cell leading edge
- midbody
- dendrite
- filopodium
- secretory granule
- Golgi transport complex
- membrane
- focal adhesion
- cell-cell junction
- plasma membrane
- cytoskeleton
- cytosol
- spindle
- centrosome
- endoplasmic reticulum membrane
- cytoplasm
- storage vacuole
- Golgi membrane
Protein families (Pfam)
InterPro annotations
CATH domain