5ung

X-ray diffraction
2.8Å resolution

XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble cytochrome b562; Type-2 angiotensin II receptor Chain: B
Molecule details ›
Chain: B
Length: 411 amino acids
Theoretical weight: 46.51 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50052 (Residues: 35-335; Coverage: 83%)
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene names: AGTR2, cybC
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLAC LCLS BEAMLINE CXI
Unit cell:
a: 70.26Å b: 78.79Å c: 93.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.262
Expression system: Spodoptera frugiperda