PDBe 5ul6

X-ray diffraction
1.45Å resolution

The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adapter molecule crk Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P46108 (Residues: 134-191; Coverage: 19%)
Gene name: CRK
Sequence domains: SH3 domain
Non-structural protein 1 Chain: M
Molecule details ›
Chain: M
Length: 15 amino acids
Theoretical weight: 1.59 KDa
Source organism: Influenza A virus
Expression system: Not provided
  • Canonical: Q99AU3 (Residues: 210-221; Coverage: 5%)
Gene name: NS

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 27.65Å b: 39.26Å c: 29.03Å
α: 90° β: 98.43° γ: 90°
R R work R free
0.168 0.167 0.187
Expression systems:
  • Escherichia coli
  • Not provided