X-ray diffraction
2.7Å resolution

The structure of Mycobacterium tuberculosis topoisomerase I from the 2nd crystal form


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA topoisomerase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 706 amino acids
Theoretical weight: 77.84 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
  • Canonical: P9WG49 (Residues: 2-704; Coverage: 75%)
Gene names: MTCY15C10.06, Rv3646c, topA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 170.573Å b: 64.412Å c: 169.345Å
α: 90° β: 112.24° γ: 90°
R R work R free
0.2 0.198 0.243
Expression system: Escherichia coli