Reviews - 5uj9 mentioned but not cited (12)
- Revisiting the role of ABC transporters in multidrug-resistant cancer. Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE, Gottesman MM. Nat Rev Cancer 18 452-464 (2018)
- Structural and functional diversity calls for a new classification of ABC transporters. Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman DP, Ueda K, Váradi A, Wen PC, Yan N, Zhang P, Zheng H, Zimmer J, Tampé R. FEBS Lett 594 3767-3775 (2020)
- Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels. Puljung MC. J Gen Physiol 150 653-669 (2018)
- Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators. M F Gonçalves B, S P Cardoso D, U Ferreira MJ. Molecules 25 E3364 (2020)
- The role of the degenerate nucleotide binding site in type I ABC exporters. Stockner T, Gradisch R, Schmitt L. FEBS Lett 594 3815-3838 (2020)
- Multidrug Resistance in Mammals and Fungi-From MDR to PDR: A Rocky Road from Atomic Structures to Transport Mechanisms. Khunweeraphong N, Kuchler K. Int J Mol Sci 22 4806 (2021)
- Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models. Lusvarghi S, Robey RW, Gottesman MM, Ambudkar SV. F1000Res 9 F1000 Faculty Rev-17 (2020)
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- A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance. Huang J, Ecker GF. Molecules 28 495 (2023)
- How Cryo-EM Has Expanded Our Understanding of Membrane Transporters. Baril SA, Gose T, Schuetz JD. Drug Metab Dispos 51 904-922 (2023)
- Microbiology catches the cryo-EM bug. Earl LA, Falconieri V, Subramaniam S. Curr Opin Microbiol 43 199-207 (2018)
- Detergents and alternatives in cryo-EM studies of membrane proteins. Li S. Acta Biochim Biophys Sin (Shanghai) 54 1049-1056 (2022)
Articles - 5uj9 mentioned but not cited (17)
- Ins and outs of AlphaFold2 transmembrane protein structure predictions. Hegedűs T, Geisler M, Lukács GL, Farkas B. Cell Mol Life Sci 79 73 (2022)
- Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses. Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S. Elife 9 e56451 (2020)
- Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses. Pierman B, Toussaint F, Bertin A, Lévy D, Smargiasso N, De Pauw E, Boutry M. J Biol Chem 292 19491-19502 (2017)
- Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters. Bickers SC, Benlekbir S, Rubinstein JL, Kanelis V. Proc Natl Acad Sci U S A 118 e2025853118 (2021)
- Multidrug resistance-associated protein 4 is a bile transporter of Clonorchis sinensis simulated by in silico docking. Dai F, Yoo WG, Lee JY, Lu Y, Pak JH, Sohn WM, Hong SJ. Parasit Vectors 10 578 (2017)
- Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter. Ran Y, Zheng A, Thibodeau PH. J Biol Chem 293 15855-15866 (2018)
- Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics. Becerra E, Aguilera-Durán G, Berumen L, Romo-Mancillas A, García-Alcocer G. Molecules 26 1051 (2021)
- The Structure and Mechanism of Drug Transporters. Roberts AG. Methods Mol Biol 2342 193-234 (2021)
- Development of Novel Intramolecular FRET-Based ABC Transporter Biosensors to Identify New Substrates and Modulators. Osa-Andrews B, Tan KW, Sampson A, Iram SH. Pharmaceutics 10 E186 (2018)
- Extracellular mutation induces an allosteric effect across the membrane and hampers the activity of MRP1 (ABCC1). Bin Kanner Y, Ganoth A, Tsfadia Y. Sci Rep 11 12024 (2021)
- Quantitative comparison of ABC membrane protein type I exporter structures in a standardized way. Csizmadia G, Farkas B, Spagina Z, Tordai H, Hegedűs T. Comput Struct Biotechnol J 16 396-403 (2018)
- Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter. Smith EE, Conseil G, Cole SPC. PLoS One 16 e0246727 (2021)
- On the interplay between lipids and asymmetric dynamics of an NBS degenerate ABC transporter. Tóth Á, Janaszkiewicz A, Crespi V, Di Meo F. Commun Biol 6 149 (2023)
- The First Cytoplasmic Loop in the Core Structure of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Contains Multiple Amino Acids Essential for Its Expression. Conseil G, Cole SPC. Int J Mol Sci 22 9710 (2021)
- The Alternating Access Mechanism in Mammalian Multidrug Resistance Transporters and Their Bacterial Homologs. Badiee SA, Isu UH, Khodadadi E, Moradi M. Membranes (Basel) 13 568 (2023)
- Identification of Novel Rare ABCC1 Transporter Mutations in Tumor Biopsies of Cancer Patients. Kadioglu O, Saeed M, Munder M, Spuller A, Greten HJ, Efferth T. Cells 9 E299 (2020)
- Modulation of Multidrug Resistance Protein 1-mediated Transport Processes by the Antiviral Drug Ritonavir in Cultured Primary Astrocytes. Arend C, Grothaus IL, Waespy M, Ciacchi LC, Dringen R. Neurochem Res 49 66-84 (2024)
Reviews citing this publication (34)
- Multidrug efflux pumps: structure, function and regulation. Du D, Wang-Kan X, Neuberger A, van Veen HW, Pos KM, Piddock LJV, Luisi BF. Nat Rev Microbiol 16 523-539 (2018)
- Cryo-EM in drug discovery: achievements, limitations and prospects. Renaud JP, Chari A, Ciferri C, Liu WT, Rémigy HW, Stark H, Wiesmann C. Nat Rev Drug Discov 17 471-492 (2018)
- Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment. Waghray D, Zhang Q. J Med Chem 61 5108-5121 (2018)
- Microglia/Astrocytes-Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors. Matias D, Balça-Silva J, da Graça GC, Wanjiru CM, Macharia LW, Nascimento CP, Roque NR, Coelho-Aguiar JM, Pereira CM, Dos Santos MF, Pessoa LS, Lima FRS, Schanaider A, Ferrer VP, Tania Cristina Leite de Sampaio e Spohr, Moura-Neto V. Front Cell Neurosci 12 235 (2018)
- Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective. Greene NP, Kaplan E, Crow A, Koronakis V. Front Microbiol 9 950 (2018)
- Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance. Xiao H, Zheng Y, Ma L, Tian L, Sun Q. Front Pharmacol 12 648407 (2021)
- ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance. Muriithi W, Macharia LW, Heming CP, Echevarria JL, Nyachieo A, Filho PN, Neto VM. Cancer Biol Med 17 253-269 (2020)
- Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters. Srikant S, Gaudet R. Nat Struct Mol Biol 26 792-801 (2019)
- ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine. Juan-Carlos PM, Perla-Lidia PP, Stephanie-Talia MM, Mónica-Griselda AM, Luz-María TE. Mol Biol Rep 48 1883-1901 (2021)
- Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM. J Biol Chem 296 100557 (2021)
- Efflux proteins at the blood-brain barrier: review and bioinformatics analysis. Saidijam M, Karimi Dermani F, Sohrabi S, Patching SG. Xenobiotica 48 506-532 (2018)
- Pleiotropic Roles of ABC Transporters in Breast Cancer. He J, Fortunati E, Liu DX, Li Y. Int J Mol Sci 22 3199 (2021)
- Structures of ABC transporters: handle with care. Lewinson O, Orelle C, Seeger MA. FEBS Lett 594 3799-3814 (2020)
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- Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications. Yang Q, Xu J, Gu J, Shi H, Zhang J, Zhang J, Chen ZS, Fang X, Zhu T, Zhang X. Adv Sci (Weinh) 9 e2201609 (2022)
- Antimicrobial Resistance and Inorganic Nanoparticles. Balderrama-González AS, Piñón-Castillo HA, Ramírez-Valdespino CA, Landeros-Martínez LL, Orrantia-Borunda E, Esparza-Ponce HE. Int J Mol Sci 22 12890 (2021)
- Moving the Cellular Peptidome by Transporters. Abele R, Tampé R. Front Cell Dev Biol 6 43 (2018)
- ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1. Arana MR, Altenberg GA. Curr Med Chem 26 1062-1078 (2019)
- Lipid environment of membrane proteins in cryo-EM based structural analysis. Mio K, Sato C. Biophys Rev 10 307-316 (2018)
- Structural snapshot of the cholesterol-transport ATP-binding cassette proteins 1. Xavier BM, Jennings WJ, Zein AA, Wang J, Lee JY. Biochem Cell Biol 97 224-233 (2019)
- Chemical tools for membrane protein structural biology. Zhang Q, Cherezov V. Curr Opin Struct Biol 58 278-285 (2019)
- Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters. Zhang XC, Liu M, Lu G, Heng J. Protein Sci 27 595-613 (2018)
- Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies. Vázquez-Meza H, Vilchis-Landeros MM, Vázquez-Carrada M, Uribe-Ramírez D, Matuz-Mares D. Antioxidants (Basel) 12 834 (2023)
- A critical review on modulators of Multidrug Resistance Protein 1 in cancer cells. Poku VO, Iram SH. PeerJ 10 e12594 (2022)
- Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters. Sajid A, Rahman H, Ambudkar SV. Nat Rev Cancer 23 762-779 (2023)
- The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs. Chetri S. Front Microbiol 14 1149418 (2023)
- Leukotrienes vs. Montelukast-Activity, Metabolism, and Toxicity Hints for Repurposing. Marques CF, Marques MM, Justino GC. Pharmaceuticals (Basel) 15 1039 (2022)
- Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor. Li J, Guo S, Sun Z, Fu Y. Front Cell Dev Biol 10 808591 (2022)
- Review on Bortezomib Resistance in Multiple Myeloma and Potential Role of Emerging Technologies. Kozalak G, Bütün İ, Toyran E, Koşar A. Pharmaceuticals (Basel) 16 111 (2023)
- Research Methods and New Advances in Drug-Drug Interactions Mediated by Renal Transporters. Lin K, Kong X, Tao X, Zhai X, Lv L, Dong D, Yang S, Zhu Y. Molecules 28 5252 (2023)
- Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance. Fan W, Shao K, Luo M. Biomolecules 14 231 (2024)
- Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis. Korbecki J, Rębacz-Maron E, Kupnicka P, Chlubek D, Baranowska-Bosiacka I. Cancers (Basel) 15 946 (2023)
- TRPM2 Channels: A Potential Therapeutic Target in Melanoma? Foster HM, Carle MN, Jira LR, Koh DW. Int J Mol Sci 24 10437 (2023)
- The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action. Devine K, Villalobos E, Kyle CJ, Andrew R, Reynolds RM, Stimson RH, Nixon M, Walker BR. Nat Rev Endocrinol 19 112-124 (2023)
Articles citing this publication (92)
- Molecular Structure of the Human CFTR Ion Channel. Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J. Cell 169 85-95.e8 (2017)
- Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP. Nat Struct Mol Biol 25 333-340 (2018)
- Structure, lipid scrambling activity and role in autophagosome formation of ATG9A. Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T. Nat Struct Mol Biol 27 1194-1201 (2020)
- Structural basis of MsbA-mediated lipopolysaccharide transport. Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M. Nature 549 233-237 (2017)
- Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states. Manolaridis I, Jackson SM, Taylor NMI, Kowal J, Stahlberg H, Locher KP. Nature 563 426-430 (2018)
- Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells. Nanayakkara AK, Follit CA, Chen G, Williams NS, Vogel PD, Wise JG. Sci Rep 8 967 (2018)
- Molecular structure of human KATP in complex with ATP and ADP. Lee KPK, Chen J, MacKinnon R. Elife 6 e32481 (2017)
- Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP. Proc Natl Acad Sci U S A 115 E1973-E1982 (2018)
- Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM. Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng SL. Elife 6 e31054 (2017)
- Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors. Dastvan R, Mishra S, Peskova YB, Nakamoto RK, Mchaourab HS. Science 364 689-692 (2019)
- PROTEINS, INTERFACES, AND CRYO-EM GRIDS. Glaeser RM. Curr Opin Colloid Interface Sci 34 1-8 (2018)
- The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion. Khunweeraphong N, Stockner T, Kuchler K. Sci Rep 7 13767 (2017)
- Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM. Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL. Elife 8 e46417 (2019)
- An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity. Debruycker V, Hutchin A, Masureel M, Ficici E, Martens C, Legrand P, Stein RA, Mchaourab HS, Faraldo-Gómez JD, Remaut H, Govaerts C. Nat Struct Mol Biol 27 829-835 (2020)
- Structure-function relationships in ABCG2: insights from molecular dynamics simulations and molecular docking studies. Ferreira RJ, Bonito CA, Cordeiro MNDS, Ferreira MU, Dos Santos DJVA. Sci Rep 7 15534 (2017)
- ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas. Demurtas OC, de Brito Francisco R, Diretto G, Ferrante P, Frusciante S, Pietrella M, Aprea G, Borghi L, Feeney M, Frigerio L, Coricello A, Costa G, Alcaro S, Martinoia E, Giuliano G. Plant Cell 31 2789-2804 (2019)
- An ABCC-type transporter endowing glyphosate resistance in plants. Pan L, Yu Q, Wang J, Han H, Mao L, Nyporko A, Maguza A, Fan L, Bai L, Powles S. Proc Natl Acad Sci U S A 118 e2100136118 (2021)
- Molecular basis of cholesterol efflux via ABCG subfamily transporters. Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X. Proc Natl Acad Sci U S A 118 e2110483118 (2021)
- ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Maltbaek JH, Cambier S, Snyder JM, Stetson DB. Immunity 55 1799-1812.e4 (2022)
- Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Long T, Hassan A, Thompson BM, McDonald JG, Wang J, Li X. Nat Commun 10 2452 (2019)
- Letter Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. Xu D, Feng Z, Hou WT, Jiang YL, Wang L, Sun L, Zhou CZ, Chen Y. Cell Res 29 1039-1041 (2019)
- Flexible-to-rigid transition is central for substrate transport in the ABC transporter BmrA from Bacillus subtilis. Lacabanne D, Orelle C, Lecoq L, Kunert B, Chuilon C, Wiegand T, Ravaud S, Jault JM, Meier BH, Böckmann A. Commun Biol 2 149 (2019)
- Structural basis of substrate recognition by a polypeptide processing and secretion transporter. Kieuvongngam V, Olinares PDB, Palillo A, Oldham ML, Chait BT, Chen J. Elife 9 e51492 (2020)
- A Comprehensive Analysis of Anion-Quadrupole Interactions in Protein Structures. Chakravarty S, Ung AR, Moore B, Shore J, Alshamrani M. Biochemistry 57 1852-1867 (2018)
- Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer. Gu J, Huang W, Wang X, Zhang J, Tao T, Zheng Y, Liu S, Yang J, Chen ZS, Cai CY, Li J, Wang H, Fan Y. Mol Cancer 21 112 (2022)
- Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets. Cox MH, Kapoor P, Briggs DA, Kerr ID. Biochem J 475 1553-1567 (2018)
- Letter Cryo-EM structure of human bile salts exporter ABCB11. Wang L, Hou WT, Chen L, Jiang YL, Xu D, Sun L, Zhou CZ, Chen Y. Cell Res 30 623-625 (2020)
- Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1. Nasr R, Lorendeau D, Khonkarn R, Dury L, Pérès B, Boumendjel A, Cortay JC, Falson P, Chaptal V, Baubichon-Cortay H. Sci Rep 10 7616 (2020)
- A structural framework for unidirectional transport by a bacterial ABC exporter. Fan C, Kaiser JT, Rees DC. Proc Natl Acad Sci U S A 117 19228-19236 (2020)
- Combining theoretical and experimental data to decipher CFTR 3D structures and functions. Hoffmann B, Elbahnsi A, Lehn P, Décout JL, Pietrucci F, Mornon JP, Callebaut I. Cell Mol Life Sci 75 3829-3855 (2018)
- Cryo-EM grid optimization for membrane proteins. Kampjut D, Steiner J, Sazanov LA. iScience 24 102139 (2021)
- Reversal Effect of ALK Inhibitor NVP-TAE684 on ABCG2-Overexpressing Cancer Cells. Wang J, Wang JQ, Cai CY, Cui Q, Yang Y, Wu ZX, Dong X, Zeng L, Zhao L, Yang DH, Chen ZS. Front Oncol 10 228 (2020)
- Cryo-electron microscopy structure of human ABCB6 transporter. Wang C, Cao C, Wang N, Wang X, Wang X, Zhang XC. Protein Sci 29 2363-2374 (2020)
- Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology. Abrusán G, Marsh JA. Cell Rep 22 3265-3276 (2018)
- Molecular insights into the human ABCB6 transporter. Song G, Zhang S, Tian M, Zhang L, Guo R, Zhuo W, Yang M. Cell Discov 7 55 (2021)
- Optimizing the flavanone core toward new selective nitrogen-containing modulators of ABC transporters. Ferreira RJ, Baptista R, Moreno A, Madeira PG, Khonkarn R, Baubichon-Cortay H, Dos Santos DJ, Falson P, Ferreira MU. Future Med Chem 10 725-741 (2018)
- An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy. Pei Y, Li M, Hou Y, Hu Y, Chu G, Dai L, Li K, Xing Y, Tao B, Yu Y, Xue C, He Y, Luo Z, Cai K. Nanoscale 10 11418-11429 (2018)
- Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy. Bock C, Zollmann T, Lindt KA, Tampé R, Abele R. Sci Rep 9 11884 (2019)
- Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. Chen Y, Yuan X, Xiao Z, Jin H, Zhang L, Liu Z. PLoS One 13 e0205175 (2018)
- Distinct allosteric mechanisms of first-generation MsbA inhibitors. Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M. Science 374 580-585 (2021)
- Genome-wide identification of FHL1 as a powerful prognostic candidate and potential therapeutic target in acute myeloid leukaemia. Fu Y, Xu M, Cui Z, Yang Z, Zhang Z, Yin X, Huang X, Zhou M, Wang X, Chen C. EBioMedicine 52 102664 (2020)
- Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibility of ATP-Binding Cassette Transporters. Srikant S, Gaudet R, Murray AW. Curr Biol 30 1689-1702.e6 (2020)
- The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation. Khandelwal NK, Millan CR, Zangari SI, Avila S, Williams D, Thaker TM, Tomasiak TM. Nat Commun 13 1278 (2022)
- ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis. Kumari S, Kumar M, Khandelwal NK, Kumari P, Varma M, Vishwakarma P, Shahi G, Sharma S, Lynn AM, Prasad R, Gaur NA, Gaur NA. PLoS One 13 e0202993 (2018)
- Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2. Horsey AJ, Briggs DA, Holliday ND, Briddon SJ, Kerr ID. Biochim Biophys Acta Biomembr 1862 183218 (2020)
- Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose. Carrier DJ, van Roermund CWT, Schaedler TA, Rong HL, IJlst L, Wanders RJA, Baldwin SA, Waterham HR, Theodoulou FL, Baker A. Sci Rep 9 10502 (2019)
- Overexpression of ABCC1 Confers Drug Resistance to Betulin. Chen XY, Yang Y, Wang JQ, Wu ZX, Li J, Chen ZS. Front Oncol 11 640656 (2021)
- Structural elucidation of transmembrane domain zero (TMD0) of EcdL: A multidrug resistance-associated protein (MRP) family of ATP-binding cassette transporter protein revealed by atomistic simulation. Bera K, Rani P, Kishor G, Agarwal S, Kumar A, Singh DV. J Biomol Struct Dyn 36 2938-2950 (2018)
- An Outward-Facing Aromatic Amino Acid Is Crucial for Signaling between the Membrane-Spanning and Nucleotide-Binding Domains of Multidrug Resistance Protein 1 (MRP1; ABCC1). Weigl KE, Conseil G, Rothnie AJ, Arama M, Tsfadia Y, Cole SPC. Mol Pharmacol 94 1069-1078 (2018)
- Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells. Li S, Liu XY, Pan Q, Wu J, Liu ZH, Wang Y, Liu M, Zhang XL. Viruses 11 E378 (2019)
- Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer. Dong Y, Liao H, Yu J, Fu H, Zhao, Gong K, Wang Q, Duan Y. J Nanobiotechnology 17 125 (2019)
- Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer. Ruan L, Chen J, Du C, Lu H, Zhang J, Cai X, Dou R, Lin W, Chai Z, Nie G, Hu Y. Bioact Mater 13 191-199 (2022)
- Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Chaptal V, Zampieri V, Wiseman B, Orelle C, Martin J, Nguyen KA, Gobet A, Di Cesare M, Magnard S, Javed W, Eid J, Kilburg A, Peuchmaur M, Marcoux J, Monticelli L, Hogbom M, Schoehn G, Jault JM, Boumendjel A, Falson P. Sci Adv 8 eabg9215 (2022)
- Transporters Revealed. Lee JY, Rosenbaum DM. Cell 168 951-953 (2017)
- Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Thaker TM, Mishra S, Zhou W, Mohan M, Tang Q, Faraldo-Goméz JD, Mchaourab HS, Tomasiak TM. Nat Chem Biol 18 226-235 (2022)
- Glutathione binding to the plant AtAtm3 transporter and implications for the conformational coupling of ABC transporters. Fan C, Rees DC. Elife 11 e76140 (2022)
- Insights on the structure-function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies. Wang JQ, Cui Q, Lei ZN, Teng QX, Ji N, Lin L, Liu Z, Chen ZS. MedComm (2020) 2 221-235 (2021)
- The assessment of the serum levels of TWEAK and prostaglandin F2α in COVID – 19 Yalçın Kehribar D, Cihangiroğlu M, Sehmen E, Avcı B, Çapraz M, Boran M, Günaydin C, Özgen M. Turk J Med Sci 50 1786-1791 (2020)
- CD19 CAR antigen engagement mechanisms and affinity tuning. He C, Mansilla-Soto J, Khanra N, Hamieh M, Bustos V, Paquette AJ, Garcia Angus A, Shore DM, Rice WJ, Khelashvili G, Sadelain M, Meyerson JR. Sci Immunol 8 eadf1426 (2023)
- Computational Insights into Allosteric Conformational Modulation of P-Glycoprotein by Substrate and Inhibitor Binding. Xing J, Huang S, Heng Y, Mei H, Pan X. Molecules 25 E6006 (2020)
- Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4. Hardy D, Bill RM, Jawhari A, Rothnie AJ. SLAS Discov 24 1000-1008 (2019)
- Mutagenic Analysis of the Putative ABCC6 Substrate-Binding Cavity Using a New Homology Model. Szeri F, Corradi V, Niaziorimi F, Donnelly S, Conseil G, Cole SPC, Tieleman DP, van de Wetering K. Int J Mol Sci 22 6910 (2021)
- Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer. Ni W, Fan H, Zheng X, Xu F, Wu Y, Li X, Wang A, Huang S, Chen W, Wang S, Lu Y. Front Oncol 11 624811 (2021)
- Drug-dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from Streptococcus pneumoniae. Guffick C, Hsieh PY, Ali A, Shi W, Howard J, Chinthapalli DK, Kong AC, Salaa I, Crouch LI, Ansbro MR, Isaacson SC, Singh H, Barrera NP, Nair AV, Robinson CV, Deery MJ, van Veen HW. FEBS J 289 3770-3788 (2022)
- Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL. Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V, Abele R. Sci Rep 8 15662 (2018)
- A Conserved Motif in Intracellular Loop 1 Stabilizes the Outward-Facing Conformation of TmrAB. Millan CR, Francis M, Khandelwal NK, Thompson VF, Thaker TM, Tomasiak TM. J Mol Biol 433 166834 (2021)
- Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1. Claxton DP, Overway EM, Oeser JK, O'Brien RM, Mchaourab HS. J Biol Chem 298 101520 (2022)
- Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches. Wise JG, Nanayakkara AK, Aljowni M, Chen G, De Oliveira MC, Ammerman L, Olengue K, Lippert AR, Vogel PD. J Med Chem 62 10645-10663 (2019)
- Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study. Sabet Z, Vagiannis D, Budagaga Y, Zhang Y, Novotná E, Hanke I, Rozkoš T, Hofman J. Int J Mol Sci 23 14338 (2022)
- Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. Kelly AM, Berry MR, Tasker SZ, McKee SA, Fan TM, Hergenrother PJ. J Am Chem Soc 144 12367-12380 (2022)
- The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase. Park JG, Kim S, Jang E, Choi SH, Han H, Ju S, Kim JW, Min DS, Jin MS. Nat Commun 13 5851 (2022)
- Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles. Loo TW, Clarke DM. Biochem Biophys Res Commun 488 573-577 (2017)
- Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis. Zhang L, Lu X, Xu Y, La X, Tian J, Li A, Li H, Wu C, Xi Y, Song G, Zhou Z, Bai W, An L, Li Z. Cell Death Dis 14 582 (2023)
- A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Pietz HL, Abbas A, Johnson ZL, Oldham ML, Suga H, Chen J. Proc Natl Acad Sci U S A 120 e2220012120 (2023)
- Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX. Pan D, Oyama R, Sato T, Nakane T, Mizunuma R, Matsuoka K, Joti Y, Tono K, Nango E, Iwata S, Nakatsu T, Kato H. IUCrJ 9 134-145 (2022)
- Structural Studies of Multidrug Resistance Protein 1 Using "Almost" Cysless Template. Trofimova DN, Deeley RG. Drug Metab Dispos 46 794-804 (2018)
- The first intracellular loop is essential for the catalytic cycle of the human ABCG2 multidrug resistance transporter. Khunweeraphong N, Kuchler K. FEBS Lett 594 4059-4075 (2020)
- Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein. Pulukuri AJ, Burt AJ, Opp LK, McDowell CM, Davaritouchaee M, Nielsen AE, Mancini RJ. Pharmaceuticals (Basel) 14 1292 (2021)
- Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. Wang J, Li X, Wang FF, Cheng MT, Mao YX, Fang SC, Wang L, Zhou CZ, Hou WT, Chen Y. EMBO J 42 e113415 (2023)
- Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling. Yu J, Chen WX, Xie WJ, Chen RW, Lin DQ, You WW, Ye WL, Zhang HQ, Lin DH, Xu JP. J Clin Lab Anal 35 e23817 (2021)
- Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4. Huang Y, Xue C, Wang L, Bu R, Mu J, Wang Y, Liu Z. Commun Biol 6 549 (2023)
- Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP. Xiong C, Jia LN, Xiong WX, Wu XT, Xiong LL, Wang TH, Zhou D, Hong Z, Liu Z, Tang L. Signal Transduct Target Ther 8 74 (2023)
- The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance. Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, Li S, Zheng W, Zhang W, Wang T, Ma X. Front Cell Dev Biol 9 797005 (2021)
- A Dual Role for Cysteinyl Leukotriene Receptors in the Pathogenesis of Corneal Infection. Carion TW, Wang Y, Stambersky A, Ebrahim AS, Berger EA. J Immunol 208 2331-2342 (2022)
- Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS. Nat Commun 14 7184 (2023)
- C-subfamily ATP binding cassette transporters extrude the calcium fluorescent probe fluo-4 from a cone photoreceptor cell line. García-de-Diego AM. Naunyn Schmiedebergs Arch Pharmacol 396 1727-1740 (2023)
- Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB. Sun S, Gao Y, Yang X, Yang X, Hu T, Liang J, Xiong Z, Ran Y, Ren P, Bai F, Guddat LW, Yang H, Rao Z, Zhang B. Protein Cell 14 448-458 (2023)
- Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR. Bin Kanner Y, Teng QX, Ganoth A, Peer D, Wang JQ, Chen ZS, Tsfadia Y. Front Pharmacol 14 1290255 (2023)
- Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein. Simon MA, Iordanov I, Szollosi A, Csanády L. Elife 12 e90736 (2023)
- Multidrug resistance protein structure of Trypanosoma evansi isolated from buffaloes in Ngawi District, Indonesia: A bioinformatics analysis. Nuryady MM, Nurcahyo RW, Hindun I, Fatmawati D. Vet World 14 33-39 (2021)
- Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning. Shi Y, Reker D, Byrne JD, Kirtane AR, Hess K, Wang Z, Navamajiti N, Young CC, Fralish Z, Zhang Z, Lopes A, Soares V, Wainer J, von Erlach T, Miao L, Langer R, Traverso G. Nat Biomed Eng (2024)
- Structural basis of prostaglandin efflux by MRP4. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. Nat Struct Mol Biol (2024)