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Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1)

Source organism: Bos taurus
Biochemical function: ABC-type transporter activity
Biological process: transmembrane transport
Cellular component: membrane

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EC 7.6.2.3: ABC-type glutathione-S-conjugate transporter

Reaction catalysed:
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, glutathione-S-conjugate-exporting)
Alternative Name(s):
  • ABCC1 (gene name)
  • Glutathione-S-conjugate-translocating ATPase
  • MRP
  • MRP1
  • Multidrug resistance-associated protein 1
  • YBT1 (gene name)
  • YCF1 (gene name)

EC 7.6.2.2: ABC-type xenobiotic transporter

Reaction catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, xenobiotic-exporting)
Alternative Name(s):
  • ATP phosphohydrolase (steroid-exporting)
  • MDR protein
  • Multidrug-resistance protein
  • P-glycoprotein
  • PDR protein
  • Pleiotropic-drug-resistance protein
  • Steroid-transporting ATPase
  • Xenobiotic-transporting ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Multidrug resistance-associated protein 1
The deposited structure of PDB entry 5uj9 contains 2 copies of Pfam domain PF00005 (ABC transporter) in Multidrug resistance-associated protein 1. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. Multidrug resistance-associated protein 1
The deposited structure of PDB entry 5uj9 contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in Multidrug resistance-associated protein 1. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Multidrug resistance-associated protein 1
IPR005292
Domain description: Multi drug resistance-associated protein
Occurring in:
  1. Multidrug resistance-associated protein 1

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