› 5ugm

X-ray diffraction
2.1Å resolution

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Edaglitazone

Released:
DOI: 10.2210/pdb5ugm/pdb
PDB entry 5ugm coloured by chain, front view.
PDB entry 5ugm coloured by chain, side view.
PDB entry 5ugm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
Shang J, Brust R, Mosure SA, Bass J, Munoz-Tello P, Lin H, Hughes TS, Tang M, Ge Q, Kamenekca TM, Kojetin DJ
Elife 7 (2018)
PMID: 30575522

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand 8A7 4 x 8A7
Ligand KNA 2 x KNA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: I4
Unit cell:
a: 128.74Å b: 128.74Å c: 93.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors.
Falomir-Lockhart et al. (2019)
10 more

5 mentions without citation

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
Shang et al. (2018)
4 more