PDBe 5ufs

X-ray diffraction
2.12Å resolution

X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with triamcinolone acetonide and SHP coregulator fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NR LBD domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 248 amino acids
Theoretical weight: 28.57 KDa
Source organism: unidentified
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A1X8XLE9 (Residues: 1-248; Coverage: 100%)
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Nuclear receptor subfamily 0 group B member 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15466 (Residues: 18-27; Coverage: 4%)
Gene names: NR0B2, SHP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 87.027Å b: 52.829Å c: 126.01Å
α: 90° β: 101.78° γ: 90°
R-values:
R R work R free
0.217 0.215 0.25
Expression systems:
  • Escherichia coli
  • Not provided