› 5tx7

X-ray diffraction
2.51Å resolution

Crystal structure of D-isomer specific 2-hydroxyacid dehydrogenase from Desulfovibrio vulgaris

Released:
DOI: 10.2210/pdb5tx7/pdb
PDB entry 5tx7 coloured by chain, front view.
PDB entry 5tx7 coloured by chain, side view.
PDB entry 5tx7 coloured by chain, top view.
Source organism: Desulfovibrio vulgaris
Entry authors: Czub MP, Shabalin IG, Gasiorowska OA, Handing KB, Kutner J, Cymborowski MT, Hennig PM, Bonanno J, Almo SC, Minor W, New York Structural Genomics Research Consortium (NYSGRC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-isomer specific 2-hydroxyacid dehydrogenase family protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 35.17 KDa
Source organism: Desulfovibrio vulgaris
Expression system: Escherichia coli
UniProt:
  • Canonical: Q72C72 (Residues: 1-326; Coverage: 100%)
Gene name: DVU_1412
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:
Ligand PEG 2 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 91.109Å b: 117.107Å c: 135.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.23
Expression system: Escherichia coli

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