5tvn

X-ray diffraction
2.9Å resolution

Crystal structure of the LSD-bound 5-HT2B receptor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2B; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 402 amino acids
Theoretical weight: 45.23 KDa
Source organisms: Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P0ABE7 (Residues: 23-123, 125-128; Coverage: 99%)
  • Canonical: P41595 (Residues: 41-248, 308-308, 313-400; Coverage: 62%)
Gene names: HTR2B, cybC
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2221
Unit cell:
a: 59.195Å b: 119.177Å c: 170.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.263
Expression system: Baculovirus expression vector pFastBac1-HM