PDBe 5tuu

X-ray diffraction
2.25Å resolution

Crystal structure of the E2F4-DP1 coiled coil and marked-box domains

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcription factor Dp-1 Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 17.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14186 (Residues: 199-350; Coverage: 37%)
Gene names: DP1, TFDP1
Sequence domains: Transcription factor DP
Transcription factor E2F4 Chain: B
Molecule details ›
Chain: B
Length: 111 amino acids
Theoretical weight: 12.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16254 (Residues: 91-198; Coverage: 26%)
Gene name: E2F4
Sequence domains: E2F transcription factor CC-MB domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Unit cell:
a: 73.575Å b: 37.55Å c: 109.942Å
α: 90° β: 103.44° γ: 90°
R-values:
R R work R free
0.207 0.205 0.239
Expression system: Escherichia coli BL21(DE3)