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Pim-1 kinase in complex with a 7-azaindole

X-ray diffraction
2.301Å resolution
PDB entry 5toe coloured by chain, front view.
PDB entry 5toe coloured by chain, side view.
PDB entry 5toe coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase pim-1
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Multimeric state: monomeric
Accessible surface area: 13172.81 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145753

Macromolecules

Serine/threonine-protein kinase pim-1
Chain: A
Length: 273 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 34-306; Coverage: 87%)
Gene name: PIM1
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase pim-1 in PDB entry 5toe, assembly 1, front view.
Serine/threonine-protein kinase pim-1 in PDB entry 5toe, assembly 1, side view.
Serine/threonine-protein kinase pim-1 in PDB entry 5toe, assembly 1, top view.
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