X-ray diffraction
1.9Å resolution

Crystal structure of human APOBEC3B N-terminal Domain


Function and Biology Details

Reaction catalysed:
Cytosine in single-stranded DNA + H(2)O = uracil in single-stranded DNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA dC->dU-editing enzyme APOBEC-3B Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
  • Canonical: Q9UH17 (Residues: 1-191; Coverage: 50%)
  • Best match: Q9UH17-2 (Residues: 1-190)
Gene name: APOBEC3B
Sequence domains: Novel AID APOBEC clade 2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 60.739Å b: 60.802Å c: 111.515Å
α: 90° β: 90° γ: 90°
R R work R free
0.189 0.188 0.203
Expression system: Escherichia coli K-12