5tk5

X-ray diffraction
1.88Å resolution

Crystal structure of human 3HAO with iron bound in the active site

Released:

Function and Biology Details

Reaction catalysed:
3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxyanthranilate 3,4-dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 290 amino acids
Theoretical weight: 32.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P46952 (Residues: 1-286; Coverage: 100%)
Gene name: HAAO
Sequence domains: 3-hydroxyanthranilic acid dioxygenase
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P6522
Unit cell:
a: 57.076Å b: 57.076Å c: 415.871Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.218
Expression system: Escherichia coli BL21(DE3)