X-ray diffraction
1.5Å resolution

Structure of 4-Hydroxytetrahydrodipicolinate Reductase from Mycobacterium tuberculosis with NADPH and 2,6 Pyridine Dicarboxylic Acid


Function and Biology Details

Reaction catalysed:
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
4-hydroxy-tetrahydrodipicolinate reductase Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 25.68 KDa
Source organism: Mycobacterium tuberculosis H37Ra
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WP23 (Residues: 1-244; Coverage: 100%)
Gene names: MTV002.38c, Rv2773c, dapB
Sequence domains:

Ligands and Environments

Cofactor: Ligand NAP 1 x NAP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6222
Unit cell:
a: 67.157Å b: 67.157Å c: 251.325Å
α: 90° β: 90° γ: 120°
R R work R free
0.149 0.148 0.169
Expression system: Escherichia coli BL21(DE3)