› 5tby

Electron Microscopy
20Å resolution

HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240)

Released:
DOI: 10.2210/pdb5tby/pdb
PDB 5tby coloured by chain and viewed from the front.
PDB 5tby coloured by chain and viewed from the side.
PDB 5tby coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Alamo L, Ware JS, Pinto A, Gillilan RE, Seidman JG, Seidman CE, Padrón R
OpenAccess logo Elife 6 (2017)
PMID: 28606303
Related structures: EMD-2240

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Myosin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1935 amino acids
Theoretical weight: 223.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12883 (Residues: 1-1935; Coverage: 100%)
Gene names: MYH7, MYHCB
Sequence domains:
Myosin light chain 3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 195 amino acids
Theoretical weight: 21.96 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08590 (Residues: 1-195; Coverage: 100%)
Gene name: MYL3
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform Chains: E, F
Molecule details ›
Chains: E, F
Length: 166 amino acids
Theoretical weight: 18.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10916 (Residues: 1-166; Coverage: 100%)
Gene names: MLC2, MYL2
Sequence domains: EF hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20Å
Relevant EMDB volumes: EMD-2240

Quick links

Citations

11 review citations

Hypertrophic Cardiomyopathy: Genetic Testing and Risk Stratification.
Stafford et al. (2021)
10 more