X-ray diffraction
4Å resolution

Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Vascular endothelial growth factor A Chains: V, W
Molecule details ›
Chains: V, W
Length: 131 amino acids
Theoretical weight: 15.2 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P15692 (Residues: 27-141; Coverage: 56%)
  • Best match: P15692-12 (Residues: 207-327)
Gene names: VEGF, VEGFA
Sequence domains: PDGF/VEGF domain
Vascular endothelial growth factor receptor 1 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 646 amino acids
Theoretical weight: 73.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P17948 (Residues: 27-656; Coverage: 48%)
Gene names: FLT, FLT1, FRT, VEGFR1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 166.71Å b: 123.09Å c: 167.37Å
α: 90° β: 109.56° γ: 90°
R R work R free
0.286 0.285 0.315
Expression systems:
  • Komagataella pastoris
  • Spodoptera frugiperda