5t4s

X-ray diffraction
2.64Å resolution

Novel Approach of Fragment-Based Lead Discovery applied to Renin Inhibitors

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: A, B
Molecule details ›
Chains: A, B
Length: 339 amino acids
Theoretical weight: 37.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P00797 (Residues: 68-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P213
Unit cell:
a: 139.927Å b: 139.927Å c: 139.927Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.258
Expression system: Homo sapiens