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Autoinhibited E. coli ATP synthase state 3

Source organism: Escherichia coli
Biochemical function: proton-transporting ATP synthase activity, rotational mechanism
Biological process: proton transmembrane transport
Cellular component: proton-transporting ATP synthase complex

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EC 7.1.2.2: H(+)-transporting two-sector ATPase

Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Systematic name:
ATP phosphohydrolase (two-sector, H(+)-transporting)
Alternative Name(s):
  • ATP synthase
  • Bacterial Ca(2+)/Mg(2+) ATPase
  • Chloroplast ATPase
  • Coupling factors (F(o), F(1) and CF(1))
  • F(0)F(1)-ATPase
  • F(1)-ATPase
  • F(o)F(1)-ATPase
  • H(+)-transporting ATP synthase
  • H(+)-transporting ATPase
  • Mitochondrial ATPase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00137
Domain description: ATP synthase subunit C
Occurring in:
  1. ATP synthase subunit c
The deposited structure of PDB entry 5t4q contains 10 copies of Pfam domain PF00137 (ATP synthase subunit C) in ATP synthase subunit c. Showing 1 copy in chain M.

PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
The deposited structure of PDB entry 5t4q contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in ATP synthase subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 5t4q contains 3 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in ATP synthase subunit beta. Showing 1 copy in chain D.

PF02874
Domain description: ATP synthase alpha/beta family, beta-barrel domain
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
The deposited structure of PDB entry 5t4q contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in ATP synthase subunit alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 5t4q contains 3 copies of Pfam domain PF02874 (ATP synthase alpha/beta family, beta-barrel domain) in ATP synthase subunit beta. Showing 1 copy in chain D.

PF00306
Domain description: ATP synthase alpha/beta chain, C terminal domain
Occurring in:
  1. ATP synthase subunit alpha
The deposited structure of PDB entry 5t4q contains 3 copies of Pfam domain PF00306 (ATP synthase alpha/beta chain, C terminal domain) in ATP synthase subunit alpha. Showing 1 copy in chain A.

PF00430
Domain description: ATP synthase B/B' CF(0)
Occurring in:
  1. ATP synthase subunit b
The deposited structure of PDB entry 5t4q contains 2 copies of Pfam domain PF00430 (ATP synthase B/B' CF(0)) in ATP synthase subunit b. Showing 1 copy in chain I.

PF00213
Domain description: ATP synthase delta (OSCP) subunit
Occurring in:
  1. ATP synthase subunit delta
The deposited structure of PDB entry 5t4q contains 1 copy of Pfam domain PF00213 (ATP synthase delta (OSCP) subunit) in ATP synthase subunit delta. Showing 1 copy in chain L.

PF00119
Domain description: ATP synthase A chain
Occurring in:
  1. ATP synthase subunit a
The deposited structure of PDB entry 5t4q contains 1 copy of Pfam domain PF00119 (ATP synthase A chain) in ATP synthase subunit a. Showing 1 copy in chain K.

PF00401
Domain description: ATP synthase, Delta/Epsilon chain, long alpha-helix domain
Occurring in:
  1. ATP synthase epsilon chain
The deposited structure of PDB entry 5t4q contains 1 copy of Pfam domain PF00401 (ATP synthase, Delta/Epsilon chain, long alpha-helix domain) in ATP synthase epsilon chain. Showing 1 copy in chain H.

PF02823
Domain description: ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Occurring in:
  1. ATP synthase epsilon chain
The deposited structure of PDB entry 5t4q contains 1 copy of Pfam domain PF02823 (ATP synthase, Delta/Epsilon chain, beta-sandwich domain) in ATP synthase epsilon chain. Showing 1 copy in chain H.

PF00231
Domain description: ATP synthase
Occurring in:
  1. ATP synthase gamma chain
The deposited structure of PDB entry 5t4q contains 1 copy of Pfam domain PF00231 (ATP synthase) in ATP synthase gamma chain. Showing 1 copy in chain G.

InterPro InterPro annotations
IPR000454
Domain description: ATP synthase, F0 complex, subunit C
Occurring in:
  1. ATP synthase subunit c
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
IPR020537
Domain description: ATP synthase, F0 complex, subunit C, DCCD-binding site
Occurring in:
  1. ATP synthase subunit c
IPR005953
Domain description: ATP synthase, F0 complex, subunit C, bacterial/chloroplast
Occurring in:
  1. ATP synthase subunit c
IPR002379
Domain description: V-ATPase proteolipid subunit C-like domain
Occurring in:
  1. ATP synthase subunit c
IPR035921
Domain description: F/V-ATP synthase subunit C superfamily
Occurring in:
  1. ATP synthase subunit c
IPR038662
Domain description: F1F0 ATP synthase subunit C superfamily
Occurring in:
  1. ATP synthase subunit c
IPR000711
Domain description: ATPase, OSCP/delta subunit
Occurring in:
  1. ATP synthase subunit delta
IPR005294
Domain description: ATP synthase, F1 complex, alpha subunit
Occurring in:
  1. ATP synthase subunit alpha
IPR000131
Domain description: ATP synthase, F1 complex, gamma subunit
Occurring in:
  1. ATP synthase gamma chain
IPR000568
Domain description: ATP synthase, F0 complex, subunit A
Occurring in:
  1. ATP synthase subunit a
IPR005722
Domain description: ATP synthase, F1 complex, beta subunit
Occurring in:
  1. ATP synthase subunit beta
IPR000793
Domain description: ATP synthase, alpha subunit, C-terminal
Occurring in:
  1. ATP synthase subunit alpha
IPR020003
Domain description: ATPase, alpha/beta subunit, nucleotide-binding domain, active site
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
IPR004100
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
IPR036121
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit alpha
  2. ATP synthase subunit beta
IPR002146
Domain description: ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast
Occurring in:
  1. ATP synthase subunit b
IPR001469
Domain description: ATP synthase, F1 complex, delta/epsilon subunit
Occurring in:
  1. ATP synthase epsilon chain
IPR024034
Domain description: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
Occurring in:
  1. ATP synthase subunit beta
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP synthase subunit beta
IPR038376
Domain description: ATP synthase, alpha subunit, C-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit alpha
IPR033732
Domain description: ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
Occurring in:
  1. ATP synthase subunit alpha
IPR023366
Domain description: ATP synthase subunit alpha, N-terminal domain-like superfamily
Occurring in:
  1. ATP synthase subunit alpha
IPR026015
Domain description: F1F0 ATP synthase OSCP/delta subunit, N-terminal domain superfamily
Occurring in:
  1. ATP synthase subunit delta
IPR035908
Domain description: ATP synthase, F0 complex, subunit A superfamily
Occurring in:
  1. ATP synthase subunit a
IPR028987
Domain description: F-type ATP synthase subunit B-like, membrane domain superfamily
Occurring in:
  1. ATP synthase subunit b
IPR005864
Domain description: ATP synthase, F0 complex, subunit b, bacterial
Occurring in:
  1. ATP synthase subunit b
IPR036771
Domain description: F0F1 ATP synthase delta/epsilon subunit, N-terminal
Occurring in:
  1. ATP synthase epsilon chain
IPR020781
Domain description: ATPase, OSCP/delta subunit, conserved site
Occurring in:
  1. ATP synthase subunit delta
IPR023011
Domain description: ATP synthase, F0 complex, subunit A, active site
Occurring in:
  1. ATP synthase subunit a
IPR045082
Domain description: ATP synthase, F0 complex, subunit A, bacterial/chloroplast
Occurring in:
  1. ATP synthase subunit a
IPR020547
Domain description: ATP synthase epsilon subunit, C-terminal domain
Occurring in:
  1. ATP synthase epsilon chain
IPR036794
Domain description: ATP synthase delta/epsilon subunit, C-terminal domain superfamily
Occurring in:
  1. ATP synthase epsilon chain
IPR020546
Domain description: ATP synthase, F1 complex, delta/epsilon subunit, N-terminal
Occurring in:
  1. ATP synthase epsilon chain
IPR023632
Domain description: ATP synthase, F1 complex, gamma subunit conserved site
Occurring in:
  1. ATP synthase gamma chain
IPR035968
Domain description: ATP synthase, F1 complex, gamma subunit superfamily
Occurring in:
  1. ATP synthase gamma chain

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