› 5t4d

Electron Microscopy
3Å resolution

Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703

Released:
DOI: 10.2210/pdb5t4d/pdb
PDB entry 5t4d coloured by chain, front view.
PDB entry 5t4d coloured by chain, side view.
PDB entry 5t4d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E
Cell 167 763-773.e11 (2016)
PMID: 27768895
Related structures: EMD-8354

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 510 amino acids
Theoretical weight: 59.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13563 (Residues: 198-702; Coverage: 52%)
Gene names: PKD2, TRPP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3Å
Relevant EMDB volumes: EMD-8354
Expression system: Homo sapiens

Quick links

Citations

42 review citations

Polycystins, ADPKD, and Cardiovascular Disease.
Kuo et al. (2020)
41 more

32 mentions without citation

Advances in TRP channel drug discovery: from target validation to clinical studies.
Koivisto et al. (2022)
31 more