› 5szq

X-ray diffraction
2.61Å resolution

Protocadherin Gamma A4 extracellular cadherin domains 3-6

Released:
DOI: 10.2210/pdb5szq/pdb
PDB entry 5szq coloured by chain, front view.
PDB entry 5szq coloured by chain, side view.
PDB entry 5szq coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
γ-Protocadherin structural diversity and functional implications.
Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L
Elife 5 (2016)
PMID: 27782885

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protocadherin gamma-A4 Chain: A
Molecule details ›
Chain: A
Length: 441 amino acids
Theoretical weight: 48.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91XY4 (Residues: 237-669; Coverage: 48%)
Gene name: Pcdhga4
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand MAN 6 x MAN
Ligand NAG 1 x NAG
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 31.89Å b: 63.64Å c: 344.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.251 0.282
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Regulation of neural circuit formation by protocadherins.
Peek et al. (2017)
11 more

2 mentions without citation

γ-Protocadherin structural diversity and functional implications.
Goodman et al. (2016)
1 more