PDBe 5syz

X-ray diffraction
1.93Å resolution

Human Liver Receptor Homologue-1 (LRH-1) Bound to a RJW100 stereoisomer and a Fragment of TIF-2


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor subfamily 5 group A member 2 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.97 KDa
Source organism: Homo sapiens
Expression system: Enterobacteria phage L1
  • Canonical: O00482 (Residues: 297-538; Coverage: 45%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q15596 (Residues: 740-754; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 46.312Å b: 46.312Å c: 219.966Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.205 0.228
Expression systems:
  • Enterobacteria phage L1
  • Not provided