› 5syo

X-ray diffraction
2Å resolution

Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with Cytisine

Released:
DOI: 10.2210/pdb5syo/pdb
PDB 5syo coloured by chain and viewed from the front.
PDB 5syo coloured by chain and viewed from the side.
PDB 5syo coloured by chain and viewed from the top.
Source organisms:
Entry authors: Bobango J, Wu J, Talley IT, Talley TT

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neur_chan_LBD domain-containing protein; Neuronal acetylcholine receptor subunit alpha-3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 230 amino acids
Theoretical weight: 26.32 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 18-71, 73-198, 215-236; Coverage: 92%)
  • Canonical: P32297 (Residues: 86-86, 215-230; Coverage: 4%)
Gene names: CHRNA3, NACHRA3
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand C5E 2 x C5E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 68.596Å b: 78.077Å c: 120.343Å
α: 90° β: 93.34° γ: 90°
R-values:
R R work R free
0.205 0.204 0.227
Expression system: Homo sapiens

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