PDBe 5syn

X-ray diffraction
1.64Å resolution

Cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ML349


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Acyl-protein thioesterase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 231 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O95372 (Residues: 1-231; Coverage: 100%)
Gene names: APT2, LYPLA2
Sequence domains: Phospholipase/Carboxylesterase
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2
Unit cell:
a: 78.21Å b: 79.79Å c: 138.61Å
α: 90° β: 93.3° γ: 90°
R R work R free
0.22 0.22 0.25
Expression system: Escherichia coli