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Expanding the PP2A Interactome by Defining a B56-Specific SLiM.

Wang X, Bajaj R, Bollen M, Peti W, Page R
Structure 24 2174-2181 (2016)
Related entries: 5k6s, 5sw9

Cited: 75 times
EuropePMC logo PMID: 27998540

Abstract

Specific interactions between proteins govern essential physiological processes including signaling. Many enzymes, especially the family of serine/threonine phosphatases (PSPs: PP1, PP2A, and PP2B/calcineurin/CN), recruit substrates and regulatory proteins by binding short linear motifs (SLiMs), short sequences found within intrinsically disordered regions that mediate specific protein-protein interactions. While tremendous progress had been made in identifying where and how SLiMs bind PSPs, especially PP1 and CN, essentially nothing is known about how SLiMs bind PP2A, a validated cancer drug target. Here we describe three structures of a PP2A-SLiM interaction (B56:pS-RepoMan, B56:pS-BubR1, and B56:pSpS-BubR1), show that this PP2A-specific SLiM is defined as LSPIxE, and then use these data to discover scores of likely PP2A regulators and substrates. Together, these data provide a powerful approach not only for dissecting PP2A interaction networks in cells but also for targeting PP2A diseases, such as cancer.

Reviews - 5swf mentioned but not cited (2)

  1. Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies. Ali AM, Kunugi H. Molecules 26 1232 (2021)
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Articles - 5swf mentioned but not cited (1)

  1. Expanding the PP2A Interactome by Defining a B56-Specific SLiM. Wang X, Bajaj R, Bollen M, Peti W, Page R. Structure 24 2174-2181 (2016)


Reviews citing this publication (24)

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Articles citing this publication (48)

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