› 5svi

X-ray diffraction
1.61Å resolution

MORC3 CW domain in complex with unmodified histone H3

Released:
DOI: 10.2210/pdb5svi/pdb
PDB entry 5svi coloured by chain, front view.
PDB entry 5svi coloured by chain, side view.
PDB entry 5svi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG
Cell Rep 16 3195-3207 (2016)
PMID: 27653685

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166085 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MORC family CW-type zinc finger protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 53 amino acids
Theoretical weight: 6.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14149 (Residues: 407-454; Coverage: 5%)
Gene names: KIAA0136, MORC3, NXP2, ZCWCC3
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1
ALA-ARG-THR-LYS-GLN-THR-ALA-ARG Chains: C, D
Molecule details ›
Chains: C, D
Length: 8 amino acids
Theoretical weight: 934 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P1
Unit cell:
a: 26.5Å b: 31.06Å c: 36.09Å
α: 107.81° β: 93.44° γ: 90.21°
R-values:
R R work R free
0.186 0.183 0.221
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

MORC Proteins: Novel Players in Plant and Animal Health.
Koch et al. (2017)
4 more

1 mention without citation

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Andrews et al. (2016)