› 5s8o

X-ray diffraction
1.67Å resolution

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N01460c (space group P212121)

Released:
DOI: 10.2210/pdb5s8o/pdb
PDB entry 5s8o coloured by chain, front view.
PDB entry 5s8o coloured by chain, side view.
PDB entry 5s8o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Krojer T, Talon R, Fairhead M, Szykowska A, Burgess-Brown NA, Brennan PE, Arrowsmith CH, Edwards AM, Bountra C, von Delft F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PH-interacting protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Sequence domains: Bromodomain

Ligands and Environments

3 bound ligands:
Ligand XM4 1 x XM4
Ligand CA 2 x CA
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 47.57Å b: 57.17Å c: 91.14Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.245
Expression system: Escherichia coli

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