› 5s8l

X-ray diffraction
1.23Å resolution

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with E11289c (space group C2)

Released:
DOI: 10.2210/pdb5s8l/pdb
PDB 5s8l coloured by chain and viewed from the front.
PDB 5s8l coloured by chain and viewed from the side.
PDB 5s8l coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Krojer T, Talon R, Fairhead M, Szykowska A, Burgess-Brown NA, Brennan PE, Arrowsmith CH, Edwards AM, Bountra C, von Delft F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PH-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand 12Q 1 x 12Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 82.3Å b: 27.66Å c: 56.89Å
α: 90° β: 100.6° γ: 90°
R-values:
R R work R free
0.129 0.128 0.159
Expression system: Escherichia coli

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