X-ray diffraction
1.23Å resolution

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with E11289c (space group C2)

Source organism: Homo sapiens
Entry authors: Krojer T, Talon R, Fairhead M, Szykowska A, Burgess-Brown NA, Brennan PE, Arrowsmith CH, Edwards AM, Bountra C, von Delft F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
PH-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8WWQ0 (Residues: 1315-1440; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 82.3Å b: 27.66Å c: 56.89Å
α: 90° β: 100.6° γ: 90°
R R work R free
0.129 0.128 0.159
Expression system: Escherichia coli