X-ray diffraction
1.7Å resolution

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z33545544

Source organism: Homo sapiens
Entry authors: Bradshaw WJ, Newman JA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Gileadi O

Function and Biology Details

Reactions catalysed:
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Chain: A
Molecule details ›
Chain: A
Length: 463 amino acids
Theoretical weight: 52.88 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q92835 (Residues: 397-857; Coverage: 39%)
Gene names: INPP5D, SHIP, SHIP1
Sequence domains: Endonuclease/Exonuclease/phosphatase family

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 62.51Å b: 79.46Å c: 89.43Å
α: 90° β: 90° γ: 90°
R R work R free
0.232 0.23 0.27
Expression system: Spodoptera frugiperda