› 5r4g

X-ray diffraction
1.25Å resolution

PanDDA analysis group deposition -- CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF in complex with FMOPL000621a

Released:
DOI: 10.2210/pdb5r4g/pdb
PDB 5r4g coloured by chain and viewed from the front.
PDB 5r4g coloured by chain and viewed from the side.
PDB 5r4g coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Talon R, Krojer T, Fairhead M, Sethi R, Bradley AR, Aimon A, Collins P, Brandao-Neto J, Douangamath A, Wright N, MacLean E, Renjie Z, Dias A, Brennan PE, Bountra C, Arrowsmith CH, Edwards A, von Delft F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleosome-remodeling factor subunit BPTF Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12830 (Residues: 2917-3037; Coverage: 4%)
Gene names: BPTF, FAC1, FALZ
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand DMS 1 x DMS
Ligand RU4 1 x RU4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 112.416Å b: 27.464Å c: 38.423Å
α: 90° β: 96.37° γ: 90°
R-values:
R R work R free
0.185 0.184 0.208
Expression system: Escherichia coli

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