› 5qsg

X-ray diffraction
1.87Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2856434903

Released:
DOI: 10.2210/pdb5qsg/pdb
PDB 5qsg coloured by chain and viewed from the front.
PDB 5qsg coloured by chain and viewed from the side.
PDB 5qsg coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

1 bound ligand:
Ligand O1A 1 x O1A
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R32
Unit cell:
a: 99.68Å b: 99.68Å c: 99.618Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.226 0.273
Expression system: Escherichia coli

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