X-ray diffraction
2.01Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2017168803

Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R32
Unit cell:
a: 99.884Å b: 99.884Å c: 98.898Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.193 0.253
Expression system: Escherichia coli