› 5qs8

X-ray diffraction
1.47Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z1432018343

Released:
DOI: 10.2210/pdb5qs8/pdb
PDB 5qs8 coloured by chain and viewed from the front.
PDB 5qs8 coloured by chain and viewed from the side.
PDB 5qs8 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT
Sequence domains: T-box

Ligands and Environments

1 bound ligand:
Ligand O0G 1 x O0G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R32
Unit cell:
a: 99.934Å b: 99.934Å c: 99.314Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.211 0.234
Expression system: Escherichia coli

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