5qs6

X-ray diffraction
1.67Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z44592329

Released:
Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Sherestha L, Fernandez-Cid A, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: R32
Unit cell:
a: 100.094Å b: 100.094Å c: 98.876Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.243
Expression system: Escherichia coli