X-ray diffraction
1.67Å resolution

PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z198194396

Source organism: Homo sapiens
Entry authors: Newman JA, Gavard AE, Fernandez-Cid A, Sherestha L, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
T-box transcription factor T Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O15178 (Residues: 41-211; Coverage: 39%)
Gene names: T, TBXT

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P4122
Unit cell:
a: 60.02Å b: 60.02Å c: 110.05Å
α: 90° β: 90° γ: 90°
R R work R free
0.222 0.221 0.252
Expression system: Escherichia coli